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Speakers, talks and time are subject to change.
All times are EDT.
| Sunday, June 26, 2022 | |
|---|---|
| 3–9 p.m. | Registration |
| 6–6:15 p.m. | Welcome and opening remarks Pablo Ortiz, PhD, Henry Ford Health System, Detroit Michelle Gumz, PhD, University of Florida |
| 6:15–7 p.m. | Keynote Address “New frontiers in kidney research” Anna Greka MD, PhD, Broad Institute of MIT and Harvard University, Cambridge, Massachusetts |
| 7:15–8:45 p.m. | Welcome reception and dinner |
| Monday, June 27, 2022 | |
| 7 a.m.–8 p.m. | Registration |
| 7–8 a.m. | Breakfast |
| 8–10 a.m. | Session 1 Novel Insights into Circadian Clock-mediated Regulation of Kidney Function and Blood Pressure Chairs: Jennifer Pollock, PhD, FAPS, University of Alabama at Birmingham; Denisha Spires, PhD, Augusta University, Georgia |
| 8–8:25 a.m. | “New insights into the role of circadian clock proteins in renal physiology” Michelle Gumz, PhD, University of Florida |
| 8:25–8:50 a.m. | “Insights from a novel BMAL1 knockout rat” David Pollock, PhD, FAPS, University of Alabama at Birmingham |
| 8:50–9:15 a.m. | “Understanding the circadian clock in polycystic kidney disease” Reena Rao, PhD, University of Kansas Medical Center |
| 9:15–9:55 a.m. | 9:15 a.m. “Systolic blood pressure rhythms are driven by timing of food intake, the molecular clock and sex in rats” Megan Rhoads, PhD, University of Alabama at Birmingham
9:25 a.m. “Adrenal-specific KO of the circadian clock protein BMAL1 alters blood pressure rhythm” Hannah Costello, PhD, University of Florida
9:35 a.m. “Global knockout of Bmal1 dysregulates mitochondrial function and morphology in the kidney” Anne Ramsey, PhD, University of Alabama at Birmingham
9:45 a.m. “Time restricted feeding ameliorates renal damage and improves vascular metabolism in mice with diet-induced obesity” Paramita Pati, DPhil, University of Alabama at Birmingham |
| 10–10:30 a.m. | Break |
| 10:30 a.m.–12:30 p.m. | Session 2 Renal Consequences of Obesity, Metabolic Syndrome and Diabetes Chairs: Christopher Wilcox, MD, PhD, Georgetown University, Washington, D.C.;Riyaz Mohamed, PhD, Augusta University, Georgia |
| 10:30–10:55 a.m. | “Kidney responses to inhibiting SGLTs” Volker Vallon, MD, FAPS, University of California, San Diego |
| 10:55–11:20 a.m. | “Renal tubular IL-1β induces salt sensitivity in diabetes by activating renal macrophages” Jorge Giani, PhD, Cedars-Sinai Medical Center, Los Angeles |
| 11:20–11:45 a.m. | “Role of T cells in enhanced susceptibility of female Dahl rats compared to males.” Jennifer Sullivan, PhD, Augusta University, Georgia |
| 11:45 a.m.–12:25 p.m. | 11:45 a.m. “Novel insights into SGLT2 inhibition in the diabetic kidney: role of macula sensa SGLT1-NOS1 pathway” Jie Zhang, PhD, University of South Florida
11:55 a.m. “CPT1a is not required for tubular fatty acid metabolism: compensatory role for peroxisomes?” Safaa Hammoud, PhD, Washington University, St. Louis
12:05 p.m. “Vitamin D supplementation mitigates canagliflozin-induced adverse changes in phosphate and vitamin D metabolism in kidney—a protective effect on bone” Shahidzadeh Yazdi, MD, University of Maryland School of Medicine
12:15 p.m. “Sex hormones-mediated differences in mitochondrial metabolic profiles of healthy male and female Sprague Dawley rats” Ryan Schibalski, Augusta University, Georgia |
| 12:30–1:30 p.m. | Lunch and Travere workshop |
| 1:30–3 p.m. | Trainee mentoring session and workshop Jennifer Pollock, PhD, FAPS, University of Alabama at Birmingham |
| 1:30–5 p.m. | Free time |
| 5–6:30 p.m. | Poster session 1 |
| 6:30–7:30 p.m. | Dinner |
| 7:30–9:10 p.m. | Session 3 New Sensing and Signaling Pathways in the Control of Renal Function Chairs: Paolo Caceres, PhD, Henry Ford Health System, Detroit; Lauren Douma, PhD, University of Florida |
| 7:30–7:55 p.m. | “Olfactory receptor 558 and blood pressure regulation” Jennifer Pluznick, PhD, Johns Hopkins School of Medicine, Baltimore |
| 7:55–8:20 p.m. | “Modulation of estrogen receptor signaling sensitizes female mice to the development of diabetes” Blythe Shepard, PhD, Georgetown University, Washington, D.C. |
| 8:20–8:45 p.m. | “The renin cell baroreceptor is a nuclear mechanotransducer crucial for the control of homeostasis.” Maria Luisa Sequeira, MD, University of Virginia |
| 8:45–9:10 p.m. | “Conjugated bile acids are depleted during hypertension, nutritional rescue of which lowers blood pressure in the Dahl salt-sensitive rat” Bina Joe, PhD, FAPS, University Toledo, Ohio |
| Tuesday, June 28, 2022 | |
| 7 a.m.–8 p.m. | Registration |
| 7–8 a.m. | Breakfast |
| 8–10 a.m. | Session 4 JGA, renin and glomerular dynamics Chairs: Ruisheng Liu, MD, PhD, University of South Florida; Jeff Garvin, PhD, Case Western Reserve University, Cleveland |
| 8–8:25 a.m. | “Novel insights on proximal tubule injury and repair in AKI” Ina Schiessl, PhD, Aarhus University, Denmark |
| 8:25–8:50 a.m. | “Regulation of renin release from juxtaglomerular cells in diabetes” Mariela Mendez, PhD, Henry Ford Health System, Detroit |
| 8:50–9:15 a.m. | “Tissue regenerative and neuron-like interoceptive functions of the macula densa” Janos Peti-Peterdi, MD, PhD, University of Southern California |
| 9:15–9:55 a.m. | 9:15 a.m. “Discovery and functions of a neuroendothelial cell type in the kidney and beyond” Georgina Gyarmati, MD, MPH, University of Southern California
9:25 a.m. “Role of GATA3 in renin cell identity” Jesus Neyra, University of Virginia
9:35 a.m. “Endothelial semaphorin-3F promotes proximal tubule maturation: implications for diabetic kidney disease” Paulo Caceres, PhD, Henry Ford Health System
9:45 a.m. “MiR-204 in podocytes protects against the development of albuminuria and renal injury” Jing Liu, PhD, University of Rochester Medical Center, New York |
| 10–10:30 a.m. | Break |
| 10:30 a.m.–12:30 p.m. | Session 5 Immune System Contributions to Renal Tubular Transport, Hemodynamics and Hypertension Chairs: Paul O’Connor, PhD, Augusta University, Georgia; Justine Abais-Battad, PhD, Augusta University, Georgia |
| 10:30–10:55 a.m. | “Endothelium-derived ET-1 drives T cell activation and sickle cell nephropathy” Jennifer Pollock, PhD, FAPS, University of Alabama at Birmingham |
| 10:55–11:20 a.m. | “Renal vulnerability to iron-mediated inflammation and damage in lupus nephritis” Erika Boesen, PhD, University of Nebraska Medical Center |
| 11:20–11:45 a.m. | “ENaC-dependent activation of the NLRP3 inflammasome in antigen presenting cells contributes to salt-sensitive hypertension” Annet Kirabo, PhD, DVM, Vanderbilt University, Nashville, Tennessee |
| 11:45 a.m.–12:25 p.m. | 11:45 a.m. “Reactive oxygen species from T cells mediate pregnancy-specific renal damage in the Dahl SS rat” John Henry Dasinger, PhD, Augusta University, Georgia
11:55 a.m. “F4/80hi resident macrophages contribute to cisplatin-induced kidney fibrosis and M2 polarization” Sophia Sears, PhD, University of Louisville, Kentucky
12:05 p.m. “Hypertensive stimulation on the regulation of the immunological synapse interface in male and female renal endothelial cells” Alex Colvert, Medical College of South Carolina
12:15 p.m. “Gonadectomy abolishes sex differences in renal T regulatory cells in DOCA-salt hypertensive rats” Karl Diaz-Sanders, Medical College of Georgia at Augusta University |
| 12:30–1:30 p.m. | Lunch |
| 1:30–2:30 p.m. | Janssen Pharmaceutical Workshop |
| 2:30–5 p.m. | Free time |
| 5–6:30 p.m. | Poster session 2 |
| 6:30–7:30 p.m. | Dinner |
| 7:30–9:10 p.m. | Session 6 The Kidney and Hypertension Chairs: Alexander Staruschenko, PhD, FAPS, University of South Florida; Niru Ramkumar, MD, PhD, University of Utah School of Medicine |
| 7:30–7:55 p.m. | “Are histone deacetylase enzymes in the kidney involved in blood pressure regulation?” Kelly Hyndman, PhD, University of Alabama at Birmingham |
| 7:55–8:20 p.m. | “Renal metabolism and hypertension” Mingyu Liang, PhD, Medical College of Wisconsin |
| 8:20–8:45 p.m. | “Pressure natriuresis and control of salt and water: impact of sex, age and dietary potassium” Alicia McDonough, PhD, Keck School of Medicine of USC |
| 8:45–9:10 p.m. | “Mitochondrial bioenergetics in salt-sensitive hypertension: the implications of the Atrial Natriuretic Peptide” Daria Ilatovskaya, PhD, Augusta University, Georgia |
| Wednesday, June 29, 2022 | |
| 7 a.m.–8 p.m. | Registration |
| 7–8 a.m. | Breakfast |
| 8–10 a.m. | Session 7 Single Cell RNAseq and Organoids (Or Other New Methods) in Renal Physiology and Disease Chairs: David Ellison, MD, Oregon Health & Sciences University; Joo-Seop Park, PhD, Cincinnati Children's Hospital Medical Center |
| 8–8:25 a.m. | “Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease” Katalin Susztak, MD, PhD, University of Pennsylvania |
| 8:25–8:50 a.m. | “Single cell analyses of kidney injury, repair and failed repair” Ben Humphreys, MD, PhD, Washington University, St. Louis |
| 8:50–9:15 a.m. | “Using iPSC and organoids to study renal function and disease” Benjamin Freedman, PhD, University of Washington |
| 9:15–9:55 a.m. | 9:15 a.m. “The gut microbiome regulates glomerular filtration rate” Jiaojiao Xu, DSc, Johns Hopkins University, Baltimore
9:25 a.m. “Mef2 family of transcription factors promotes renin cells differentiation” Alexandre Martini, PhD, University of Virginia
9:35 a.m. “High throughput investigation of the metabolic flux of intact cortical kidney tubules” Johannes Jägers, PhD, Aarhus University, Denmark
9:45 a.m. “Compensatory changes in oxygen extraction and metabolomic profiles in the kidney of Sprague-Dawley rats fed a high-salt diet” Satoshi Shimada, MD, PhD, Medical College of Wisconsin |
| 10–10:30 a.m. | Break |
| 10:30 a.m.–12:30 p.m. | Session 8 Polycystic and Other Inherited Kidney Diseases Chairs: Reena Rao, PhD, University of Kansas Medical Center; Peter Harris, PhD, Mayo Clinic, Rochester, Minnesota |
| 10:30–10:55 a.m. | “Targeting pannexin-1 in the treatment of polycystic kidney diseases” Tengis Pavlov, PhD, Henry Ford Health System, Detroit |
| 10:55–11:20 a.m. | “The role of the Hippo/Warts pathway in PKD” Thomas Carroll, PhD, UT Southwestern Medical Center |
| 11:20–11:45 a.m. | “Roles of autophagy in kidney function and disease” Mary Choi, MD, Weill Cornell Medical College, New York |
| 11:45 a.m.–12:25 p.m. | 11:45 a.m. “Renal histaminergic system and acute effects of histamine receptor 2 blockage in salt-sensitive hypertension” Denisha Spires, PhD, Medical College of Georgia at Augusta University
11:55 a.m. “HIF-1α mediates suppression of NRF2 in severe ischemic acute kidney injury” Corina Bondi, PhD, University of Pittsburgh
12:05 p.m. “Novel renoprotective mechanism of CD14 in salt-sensitive hypertension” Emily Burns, Augusta University, Georgia
12:15 p.m. “Inhibition of RET signaling attenuates compensatory hypertrophic renal remodeling in the 5/6Nx rat model of chronic kidney disease” Amanda Marks, Medical College of Wisconsin |
| 12:30–1:30 p.m. | Lunch |
| 1:30–5 p.m. | Free time |
| 5–6:30 p.m. | Poster session 3 |
| 6:30–7:30 p.m. | Dinner |
| 7:30–9:10 p.m. | Session 9 New Ways to Study an Old Problem: Mathematical Modeling and Novel Models to Study Kidney Function and Disease Chairs: Paul Welling, MD, Johns Hopkins University School of Medicine, Baltimore; Timo Rieg, MD, PhD, University of South Florida |
| 7:30–7:55 p.m. | “Adaptive changes in renal hemodynamics and tubular transport in pregnancy, hypertension, and obesity: modeling and analysis” Anita Layton, PhD, University of Waterloo, Canada |
| 7:55–8:20 p.m. | “Assessing synchronization of renal blood flow and consequences for oxygenation perfusion matching in the kidney” Branko Braam, MD, PhD, University of Alberta, Canada |
| 8:20–8:45 p.m. | “Pig models of metabolic syndrome, renovascular hypertension and chronic kidney disease” Alejandro Chade, MD, University of Mississippi Medical Center |
| 8:45–9:10 p.m. | “Novel analytical approaches to assess renal autoregulation in conscious rats” Aaron Polichnowski, PhD, East Tennessee State University |
| Thursday, June 30, 2022 | |
| 7–10 a.m. | Registration |
| 7–8 a.m. | Breakfast |
| 8–10 a.m. | Session 10 Integrative Biology of Kidney Function and Disease: Kidney Crosstalk with Other Organs, Stress and Nerves Chairs: Leslie Gewin, MD, Washington University, St. Louis; Michael Hultström, MD, PhD, Uppsala University, Sweden |
| 8–8:25 a.m. | “Exploring metabolome-proteome interactions in kidney disease—from target discovery to functional validation” Markus Rinschen, MD, Aarhus University, Denmark |
| 8:25–8:50 a.m. | “Contribution of fat-brain-blood pressure axis to obesity-hypertension in a behavioral stress model” Analia Loria, PhD, University of Kentucky |
| 8:50–9:15 a.m. | “Novel insights into the role of renal sensory nerves in kidney physiology and pathophysiology” John Osborn PhD, University of Minnesota |
| 9:15–9:40 a.m. | “How do flies cope with a high salt diet? Urea is the key!” Aylin Rodan, PhD, University of Utah |
| 9:40–10 a.m. | 9:40 a.m. “Female rats with history of acute kidney injury develop endothelial dysfunction and renal insufficiency in pregnancy” Desmond Moronge, PhD, Augusta University, Georgia
9:50 a.m. “The role of anesthesia in the pathogenesis of aki: the impact of renal sympathetic nerve activity” Stephanie Franzen, PhD, Uppsala University, Sweden |
| 10–10:30 a.m. | Break |
| 10:30 a.m.–12:30 p.m. | Session 11 Dietary Control of Renal Function and Hypertension, Salt and Beyond Chairs: Robert Hoover, MD, Tulane University, New Orleans; Hannah Costello, PhD, University of Florida |
| 10:30–10:55 a.m. | “Zinc deficiency: New insights in hypertension” Clintoria Williams, PhD, Wright State University, Dayton, Ohio |
| 10:55–11:20 a.m. | “Chemo-sensing by the nephron to control salt reabsorption: Effects of fructose, fat and high salt on TAL NaCl reabsorption and blood pressure control” Pablo Ortiz, PhD, Henry Ford Health System, Detroit |
| 11:20–11:45 a.m. | “Amplifying responsiveness to dietary potassium imbalance via KS-WNK1” Arohan Subramanya, MD, University of Pittsburgh |
| 11:45 a.m.–12:25 p.m. | 11:45 a.m. “Protective effects of propionate and inulin in salt-sensitive hypertension and renal end organ damage” Justine Abais-Battad, PhD, Medical College of Georgia at Augusta University
11:55 a.m. “Gut microbiota modulates renal gene expression in a sex-specific manner” Brittni Moore, Johns Hopkins University School of Medicine, Baltimore
12:05 p.m. “The 5-HT1F receptor agonist lasmiditan recovers mitochondrial homeostasis and renal function after acute kidney injury” Kevin Hurtado, University of Arizona
12:15 p.m. “Renal lipid accumulation is associated with kidney injury and hyperglycemia in an obese model of ovarian hormone deficiency” Francesca Di Sole, PhD, Des Moines University, Iowa |
| Closing remarks | |
| Departure and box lunches | |
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