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- About APS
Reproducibility
A lack of consistent reproducibility in some preclinical research has serious implications for translating those findings from bench to bedside.
Avoiding Common Pitfalls in Preclinical Animal Research Design
James Fox (Massachusetts Institute of Technology), Valerie Hamilton (Merck), and Tom Cheever (NIAMS) outline key areas to focus on when designing your animal research experiments in order to improve the quality of data outcomes. (Experimental Biology 2018)
Why Scientific Rigor Matters and Ways to Improve It
Kristine Willis (NIH), Bradley K. Yoder (University of Alabama-Birmingham), Curt D. Sigmund (University of Iowa), and Tracey Weissgerber (Mayo Clinic) describe efforts to increase scientific rigor through training students in research design, more transparent reporting of research findings, and better approaches to data visualization. (Experimental Biology 2017)
Reproducibility in Research Symposium
Shai Silberberg (NINDS), Richard Nakamura (NIH-CSR), and Malcolm Macleod (Edinburgh University) identified issues that undermine scientific rigor and the importance of addressing them. (Experimental Biology 2015)
Reproducibility Tool Box
Resource collection to promote rigor in research. [PDF]
Reproducibility Journal Club
A journal club activity to gain insight into the challenges of improving scientific rigor.
NIH: Rigor and Reproducibility
Access point for NIH announcements and resources on improving scientific rigor.
NIH OER Rigor & Reproducibility Guidance
Information from the NIH Office of Extramural Research designed to assist the extramural community in addressing rigor and transparency in NIH grant applications and progress reports.
iBiology: Shai Silberberg Video on Unconscious Bias & Publications Bias
In a video produced by iBiology, NINDS Program Director Shai Silberberg discusses two key contributors to irreproducibility and offers suggestions for mitigating these factors.
ILAR Workshop Brief: Reproducibility in Research with Animal Models
A summary of the National Academy of Sciences's Roundtable on Science and Welfare in Laboratory Animal Use. The document is available as a free PDF download or to read online.
NIH One Pager on Reproducibility in Grant Applications
A One Pager by NIH breaking down various aspects of reproducibility and rigor and explaining where they should be addressed in grant applications. [PDF])
NIH Frequently Asked Questions
NIH FAQ on rigor and reproducibility.
Early-career Advocacy Fellowship
Do you want to improve your outreach skills and learn more about science policy? Apply for our Early-career Advocacy Fellowship! This two-year program engages early career investigators in advocacy activities and provides them with skills to become long-term advocates for scientific research.
Scientific Workforce
APS advocates for policies that support the scientific workforce, including researchers of any gender, race, age, and career stage.
Data Management and Sharing
The updated NIH Data Management and Sharing Policy will take effect for grant applications received on or after January 25, 2023. Learn about the new requirements through these resources:
Recent Comments and Letters
- APS Comment on FDA-NIH Workshop on Reducing Animal Testing
- Letter to Congress on FY 2026 NIH Funding
- Letter to Congress on FY 2026 NSF Funding
- APS Comment on Reclassifying Civil Servants
- NIH Re-envisioning U.S. Postdoctoral Research Training and Career Progression
- NIH Sexual and Gender Minority Research
- Response to House NIH Reform Framework Proposal [PDF]
- Research Needs Support [PDF]
- On Cephalopod Care and Use
- APS Comments on Proposed Research Misconduct Policies
- On Updating NIH’s Mission Statement
- Update to the Current OLAW Guidance Disclaimer RFI
- Flexibilities for Streamlining IACUC Review RFI
- Novel Alternative Methods RFI
- Proposed Reorganization of NIGMS
- Hill Day Funding One Pager
- Recommendations for Improving NRSA Fellowship Review
- Proposed Simplified Framework for NIH Peer Review
- NSF Reauthorization [PDF]
- NIH-Wide Strategic Plan for Research on the Health of Women
- OLAW RFI on Grant to Protocol Congruency
Position Statements
- Ethical Animal Research: The 3Rs as Guiding Principles
The APS advances ethical animal research through the 3Rs: Reduction, Refinement, and Replacement.
- APS Reaffirms Animal Care Requirements
APS members are expected to be ethical in their research, especially in the use and care of animals.
- Guiding Principles for the Care and Use of Vertebrate Animals in Research and Training
Animal experiments are to be undertaken only with the purpose of advancing knowledge. Consideration should be given to the appropriateness of experimental procedures, species of animals used and number of animals required.
- Animal Research is Essential to the Search for Cures
Humane research involving animals provides unique insights into biological structure and function. These insights offer major benefits to both human and animal health.
- On the Use of Animals in Teaching
The study of living systems is an essential component of physiology instruction. Teaching laboratories that actively engage students in observation of and interaction with living systems enhance student understanding of physiology.
- APS Condemns Extremism and Harassment
The American Physiological Society unequivocally condemns the targeting of individuals engaged in legitimate scientific inquiry.
- Air Transport of Animals Advances Human and Animal Welfare
Air transportation is essential so scientists can work with animal models and is the most humane transportation option for the animals themselves.
Stay Connected
Advocacy is most effective when we work together. Stay engaged with APS advocacy efforts: