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A lack of consistent reproducibility in some preclinical research has serious implications for translating those findings from bench to bedside.

Avoiding Common Pitfalls in Preclinical Animal Research Design

James Fox (Massachusetts Institute of Technology), Valerie Hamilton (Merck), and Tom Cheever (NIAMS) outline key areas to focus on when designing your animal research experiments in order to improve the quality of data outcomes. (Experimental Biology 2018)

Why Scientific Rigor Matters and Ways to Improve It

Kristine Willis (NIH), Bradley K. Yoder (University of Alabama-Birmingham), Curt D. Sigmund (University of Iowa), and Tracey Weissgerber (Mayo Clinic) describe efforts to increase scientific rigor through training students in research design, more transparent reporting of research findings, and better approaches to data visualization. (Experimental Biology 2017)

Reproducibility in Research Symposium

Shai Silberberg (NINDS), Richard Nakamura (NIH-CSR), and Malcolm Macleod (Edinburgh University) identified issues that undermine scientific rigor and the importance of addressing them. (Experimental Biology 2015)

APS Resources
Reproducibility Tool Box

Resource collection to promote rigor in research. [PDF]

Reproducibility Journal Club

A journal club activity to gain insight into the challenges of improving scientific rigor.

Outside Resources
NIH: Rigor and Reproducibility

Access point for NIH announcements and resources on improving scientific rigor.

NIH OER Rigor & Reproducibility Guidance

Information from the NIH Office of Extramural Research designed to assist the extramural community in addressing rigor and transparency in NIH grant applications and progress reports.

iBiology: Shai Silberberg Video on Unconscious Bias & Publications Bias

In a video produced by iBiology, NINDS Program Director Shai Silberberg discusses two key contributors to irreproducibility and offers suggestions for mitigating these factors.

ILAR Workshop Brief: Reproducibility in Research with Animal Models

A summary of the National Academy of Sciences's Roundtable on Science and Welfare in Laboratory Animal Use. The document is available as a free PDF download or to read online.

NIH One Pager on Reproducibility in Grant Applications

A One Pager by NIH breaking down various aspects of reproducibility and rigor and explaining where they should be addressed in grant applications. [PDF])

NIH Frequently Asked Questions

NIH FAQ on rigor and reproducibility.



Early Career Advocacy Fellowship

An early career researcher makes her point while other scientists look on

Do you want to improve your outreach skills and learn more about science policy? Apply for our Early Career Advocacy Fellowship! This two-year program engages early career investigators in advocacy activities and provides them with skills to become long-term advocates for scientific research.

Learn More



Scientific Workforce

APS advocates for policies that support the scientific workforce, including researchers of any gender, race, age, and career stage.



Data Management and Sharing

The updated NIH Data Management and Sharing Policy will take effect for grant applications received on or after January 25, 2023. Learn about the new requirements through these resources:





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