- Membership & Community
-
Publications & News
- Journals
-
Newsroom
-
The Physiologist Magazine
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- In Depth
-
Mentoring Forum
- Net Worth
- Take Care
- You … In Charge
- Work. It. Out.
- Working Off-site
- Location, Location, Location?
- Student Support
- Progressing to Postdoc
- Relationship Building
- Let’s Get It Started
- What Do We Value?
- It’s a Postdoc Life
- Coronavirus Contributions
- Creative Communications
- Selection Process
- Conference Connections
- Postdoc Appreciation
- Research Rewards
- Focus on Teaching
- Industry Insights
- Balance Beam
- Post Postdoc
- If You Build It
- Talk It Through
- Forward Bound
- I’ve Earned My PhD. Now What?
- University Life
- Tips for Trainees
- Time Travel
- Policy IQ
- Publish with Polish
- Under the Microscope
- Mentoring Q&A
- The Physiologist Magazine Readers Survey
- Evolution
- Baseline by Scott Steen, CAE, FASAE
- Find Us on Social Media
-
The Physiologist Magazine
-
Professional Development
-
Meetings & Events
-
American Physiology Summit
- #APS2024 Overview
- Abstracts
- Awards at the Summit
- Award Lectures
- Career Networking Lunch Form
- Dates and Deadlines
- Hotel Information
- Industry Partners
- Keynote Speaker—Brian Kobilka, MD
- Keynote Speaker—Jessica Meir, PhD
- Mobile App
- NIH and NSF Program Officer Panel Discussion Form
- Off-site Summit Meetups
- Physical Poster Information
- PhysioHub
- Pre-Summit Events
- Registration
- Section & Group Banquet Tickets
- Speaker Audiovisual Instructions
- Summit FAQs
- Summit Newsroom
- Summit Store
- Travel & Transportation
- Undergraduate Program Book
- Liability Waiver
- Summit Call for Proposals
- Industry Partners
- Martin Frank Diversity Travel Award Orientation Agenda
- Martin Frank Diversity Travel Award Networking Luncheon Agenda
- Women in Physiology Networking Event Agenda
-
2023
- APS 2023 Call for Proposals
- Women in Physiology Networking Mixer Registration
- Career Networking Lunch Form
- NIH Program Officer Panel Discussion Form
- Shocklogic Test
- Team 2023 Task Force
- Shaping the Summit
- Schedule at a Glance
- Pre-Summit Events
- Pre-Summit Center for Physiology Education Workshop Registration
- Section & Groups Banquet Tickets
- Summit Store
- Pre-Summit Center for Physiology Education Workshop
- Press Registration
- Meet the Organizers
- Keynote Speaker—Terrie Williams, PhD
- Keynote Speaker—David Julius, PhD
- Industry Workshop Information
- Important Dates and Deadlines
- Hotel Information
- Game Changers
- Distinguished Lecturers
- Building APS 2023
- Awards at the Summit
- 2023 Summit Information
- American Physiology Summit Program
- 2023 Summit Newsroom
- Scientific Integrity Policy
- From Concept to Classroom
- Webinars
- Related Meetings
- Future APS Conferences
-
Past APS Conferences
- APS Institute on Teaching and Learning
- Integrative Physiology of Exercise
- Seventeenth International Conference on Endothelin (ET-17)
- New Trends in Sex and Gender Medicine
- APS Institute on Teaching and Learning (2022)
- Control of Renal Function in Health and Disease Conference
- Comparative Physiology: From Organisms to Omics in an Uncertain World
- Conference Policies
-
American Physiology Summit
- Awards
-
Career & Professional Development
-
Career Gateway
-
Resources
- Transcript—Leading Through Conflict and Difficult Conversations
- Transcript—Managing Conflict with Colleagues
- Transcript—Leading a Team Through Conflict
- Transcript—Providing Difficult Feedback
- Transcript—Team Dynamics and Culture Primer
- Transcript—Building a Team
- Transcript—Leading a Team Assigned to You
- Transcript—Creating a Team Culture
-
Resources
- Career Navigator
- Center for Physiology Education
- Job Board
- Mentoring
- APS Graduate Physiology & Biomedical Science Catalog
-
Career Gateway
-
Meetings & Events
-
Advocacy & Resources
- Policy Areas
-
Resources
- Researcher Resources
- Educator Resources
- Trainee Resources
- Student Resources
-
APS Graduate Physiology & Biomedical Science Catalog
- Augusta University
- Des Moines University
- East Tennessee State University
- George Washington University
- Louisiana State University Health Sciences Center Shreveport
- Mayo Clinic Graduate School of Biomedical Sciences—Biomedical Engineering & Physiology
- Medical College of Wisconsin
- Michigan State University
- New York Medical College
- Nova Southeastern University
- Pennsylvania State University
- Saint Louis University
- Texas A&M University
- Texas A&M University Medical Physiology
- Stony Brook University
- The University of Iowa
- The University of Mississippi Medical Center
- University of Alabama at Birmingham
- University at Buffalo
- University of Colorado
- University of Delaware
- University of Florida
- University of Louisville
- University of Michigan
- University of Minnesota
- University of Missouri-Biomedical Sciences
- University of Nebraska Medical Center
- University of Oregon
- University of South Carolina School of Medicine
- University of Tennessee Health Science Center (UTHSC)
- University of Texas Health Science Center
- Virginia Commonwealth University
- Wayne State University
- Wake Forest University
- Physiology Department Catalog Submission Form
- Career Gateway
- Diversity, Equity & Inclusion
- Advocacy
- About APS
May 26, 2021
11 a.m. EDT
Deficits in on-demand delivery of blood to active brain regions (functional hyperemia) are early manifestations of the underlying pathogenesis of Alzheimer’s and small vessel disease of the brain. The capillary endothelial cell strong inward-rectifier K+ (Kir2.1) channel, which senses neuronal activity and initiates a propagating electrical signal that dilates upstream arterioles, is a cornerstone of functional hyperemia. Impaired functional hyperemia is caused by diminished Kir2.1 channel activity. Kir2.1 deactivation is linked to depletion of phosphatidylinositol 4,5-bisphosphate (PIP2), a membrane phospholipid essential for Kir2.1 activity. Furthermore, the soluble PIP2 rescued functional hyperemia in models of Alzheimer’s and small vessel disease (CADASIL).
Speaker
Mark Nelson, PhD
University of Vermont, Burlington
Nelson is University Distinguished Professor and Chair of the Department of Pharmacology in the College of Medicine at the University of Vermont. He is a current member of the Vermont Academy of Sciences & Engineering (1999), Fellow of the American Heart Association (2001) and Fellow of the Biophysical Society (2009) and an ad hoc member of the NIH Pharmacology Study Section (regular member 1998–2002). He has served as Councilor of the Biophysical Society Council (1998–2002) and as a regular member of the NIH Pharmacology Section (1998–2002). Nelson has lectured and published widely, served as a consultant to several corporations, and has a particular research interest in the properties and roles of ion channels in smooth-muscle function.
Nelson has sparked major advances in ion channel physiology and calcium signaling in the vasculature and neurovascular coupling. He has the unique expertise to perform key measurements on single vascular cells, intact pressurized brain parenchymal arterioles and brain slices, and monitor in vivo cortical cerebral blood flow using transgenic mouse models . In collaboration with Dr. Joutel over the last year, he has established the TgPAC-Notch3R169C CADASIL mouse model in Vermont.