WEBINAR SERIES—Investigating a Novel Regulator of Atrial Contractility

October 19, 2022
11 a.m. EDT

Join David Barefield, PhD, of Loyola University Chicago, for an in-depth discussion of his research investigating the role of myosin binding protein H-like (MyBP-HL) in atrial dysfunction. MyBP-HL is an atrial myofilament protein that establishes a stoichiometry relationship with cardiac myosin binding protein-C. Loss of MyBP-HL leads to atrial dilation, arrhythmia and dilated cardiomyopathy. Barefield’s lab performed biophysical experiments on single myofibrils isolated from MyBP-HL-null mice to determine if nonsense variants prevent MyBP-HL incorporation into the myofilament or if truncation variants result in alternative protein localization within the cardiomyocyte. The webinar will discuss the research process and results of this scientific question.

Speaker

David Barefield, PhD, is an assistant professor at Loyola University Chicago. The Barefield Lab opened in May 2020 and focuses on atrial myopathies and the role of atrial dysfunction in common forms of cardiovascular disease.