WEBINAR—Strategic Approaches to Age-related Metabolic Insufficiency and Transition into Dementia Syndrome

November 7, 2022
11 a.m. EST

Brain metabolism changes with normal aging. Transient, dynamic metabolic insufficiency may underlie a critical progression from aging into dementia syndrome and Alzheimer’s disease. Metabolic insufficiency can occur when there is an intermittent supply-demand mismatch in substrate; adequacy of neurovascular coupling to provide sufficient cerebral blood flow (CBF) to meet neuronal metabolism demand in vivo in a mouse model of Alzheimer’s disease were studied and compared to aged controls. 

In this webinar, Dennis Turner, MA, MD, will discuss his lab’s work studying the relationship of neurovascular coupling to cerebral blood flow and evaluate the hypothesis that metabolic insufficiency is a critical component of degeneration leading to dementia. 

Key Topics Include: 

• defining the concept of metabolic insufficiency in Alzheimer's disease, 
• analyzing cortical responses to neuronal metabolic demands in an animal model,
• assessing the progression of Alzheimer's disease in an animal model compared to age-matched controls,  
• underscoring the need for reliable, reproducible anesthesia delivery and vital sign monitoring/recording to ensure robust data collection, and 
• identifying the mechanisms of potential treatments for metabolic insufficiency in Alzheimer's disease. 

Speaker

Dennis Turner, MA, MD, is an academic neurosurgeon scientist focused on brain research at the clinical, translational and pre-clinical levels. Turner currently performs neurosurgical procedures, particularly deep brain stimulation, in people with movement disorders. Heconducts research on both Parkinson and Alzheimer’s disease to understand their mechanisms and interventions.