WEBINAR SERIES—Control of Muscle Glucose Uptake In Vivo: Thinking outside the Myocyte

In this webinar, David Wasserman, PhD, will help attendees gain a more complete understanding of muscle glucose uptake through consideration of the integration of physiological systems that control this process. 

Additionally, Wasserman will explore using mouse models to focus on the extracellular matrix (ECM) of insulin-sensitive tissue as a control site for muscle glucose uptake and to determine if ECM components activate ligands for cell surface integrin receptors.  

Key Topics Include: 

• Muscle glucose uptake requires delivery to, transport into, and phosphorylation within the muscle cell. 
• The glucose transporter GLUT4 is contained in vesicles in the cell that are translocated to the cell surface in response to stimuli such as insulin and exercise. 
• GLUT4 abundance in the plasma membrane determines control of glucose uptake by glucose delivery and phosphorylation. 
• Inflammation that accompanies obesity causes increased extracellular matrix. 
• Extracellular matrix proteins affect insulin action by binding to integrin receptors. 

Speaker

David Wasserman, PhD 
Professor, Vanderbilt University 

David Wasserman, PhD is a professor of molecular physiology and biophysics and the Anne Marie Lyle Chair of Biomedical Sciences at Vanderbilt University in Nashville, Tennessee. Wasserman has been director of the National Institute of Diabetes and Digestive and Kidney Diseases Vanderbilt Mouse Metabolic Phenotyping Center since 2001. He is also a longtime member of the Executive Committee of the Vanderbilt Diabetes Research Center.