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February 17
11 a.m. EST

The program will introduce spiny mice and research efforts at Seattle Children’s Research Institute to make them into a traditional experimentally tractable mammalian model system. Speakers will cover basic concepts underlying mammalian brain development and aging will focus on the hippocampus, neurodegenerative disease, inflammation and aging. The session will detail the unique hippocampal biology, persistent neurogenic activity and inflammatory resiliency of the spiny mouse, and how their naturally selected solutions might be translated into better human brain health span therapeutics.

The webinar will also explore the northern elephant seal's endothelial resistance and ability to cope with oxidative stress and ferroptosis. Understanding natural mechanisms of oxidative stress avoidance or tolerance in a deep-diving marine mammal can provide insight into the balance between naturally high iron loads and redox homeostasis in a translational context.

Speakers 

Branden Nelson, PhD  
Scientist, Seattle Children's Research Institute

Branden Nelson, PhD, is a scientist at the Norcliffe Foundation Center for Integrative Brain Research at Seattle Children's Research Institute. He received his degree in biochemistry and developmental neurobiology at Montana State University. Nelson’s research focuses on neocortical and hippocampal development, pediatric brain injury (ZIKA, ischemia), inflammation, aging and regeneration versus fibrosis in multiple animal models.    

Kaitlin Allen, PhD  
Postdoctoral Scholar, Woods Hole Oceanographic Institution

Kaitlin Allen, PhD, is a postdoctoral scholar in the Department of Biology at the Woods Hole Oceanographic Institution. She earned her doctoral degree in integrative biology from the University of California, Berkeley. Allen investigates the cellular underpinnings of diving in marine mammals, including their remarkable tolerance of profound hypoxia and prolonged fasting. Her work aims to identify molecular mechanisms critical for extreme diving and fasting behaviors in marine mammals, with the goal of advancing our understanding of adaptation and resilience in both evolutionary and translational contexts.

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