- Membership & Community
-
Publications & News
- Journals
-
Newsroom
-
The Physiologist Magazine
- 2019
- 2020
- 2021
- 2022
-
Mentoring Forum
- Net Worth
- Take Care
- You … In Charge
- Work. It. Out.
- Working Off-site
- Location, Location, Location?
- Student Support
- Progressing to Postdoc
- Relationship Building
- Let’s Get It Started
- What Do We Value?
- It’s a Postdoc Life
- Coronavirus Contributions
- Creative Communications
- Selection Process
- Conference Connections
- Postdoc Appreciation
- Research Rewards
- Mentoring Q&A
- The Physiologist Magazine Readers Survey
- Evolution
- Baseline by Scott Steen, CAE, FASAE
- Find Us on Social Media
-
The Physiologist Magazine
-
Professional Development
-
Meetings & Events
- American Physiology Summit
- Experimental Biology
- APS Institute on Teaching and Learning
- Control of Renal Function in Health and Disease Conference
- Comparative Physiology: From Organisms to Omics in an Uncertain World
- Webinars
- Related Meetings
- Future APS Conferences
-
Past APS Conferences
- APS/ASN Control of Renal Function in Health and Disease Conference
- Interface of Mathematical Models and Experimental Biology: Role of the Microvasculature Conference
- Aldosterone and ENaC in Health and Disease: The Kidney and Beyond Conference
- APS Institute on Teaching and Learning
- Integrative Physiology of Exercise
- Seventeenth International Conference on Endothelin (ET-17)
- New Trends in Sex and Gender Medicine
- Conference Policies
- Awards
-
Career & Professional Development
-
Career Gateway
-
Resources
- Transcript—Leading Through Conflict and Difficult Conversations
- Transcript—Managing Conflict with Colleagues
- Transcript—Leading a Team Through Conflict
- Transcript—Providing Difficult Feedback
- Transcript—Team Dynamics and Culture Primer
- Transcript—Building a Team
- Transcript—Leading a Team Assigned to You
- Transcript—Creating a Team Culture
-
Resources
- Center for Physiology Education
- Jobs Board
- Professional Skills Training Courses
- Medical Physiology Refreshers
- Mentoring
- APS Graduate Physiology & Biomedical Science Catalog
-
Career Gateway
-
Meetings & Events
-
Advocacy & Resources
- Policy & Advocacy
-
Resources
- Researcher Resources
- Educator Resources
- Trainee Resources
- Student Resources
- COVID-19 Resources
-
APS Graduate Physiology & Biomedical Science Catalog
- Augusta University
- Brandeis University
- Chatham University
- Des Moines University
- East Carolina University
- East Tennessee State University
- George Washington University
- Kansas State University
- Kansas State University College of Veterinary Medicine
- Louisiana State University Health Sciences Center Shreveport
- Loyola University Chicago
- Marquette University
- Mayo Clinic Graduate School of Biomedical Sciences—Biomedical Engineering & Physiology
- Medical College of Wisconsin
- Michigan State University
- New York Medical College
- Nova Southeastern University
- Pennsylvania State University
- Rutgers Graduate Program in Physiology and Integrative Biology
- Saint Louis University
- Southern Illinois University
- Texas A&M University
- Texas A&M University Medical Physiology
- Stony Brook University
- The University of Arizona
- The University of Iowa
- The University of Mississippi Medical Center
- The University of Tennessee Health Science Center (UTHSC)
- The University of Texas at Arlington
- University of Alabama at Birmingham
- University at Buffalo
- University of California, Davis
- University of Colorado
- University of Delaware
- University of Georgia College of Veterinary Medicine
- University of Louisville
- University of Michigan
- University of Minnesota
- University of Missouri-Biomedical Sciences
- University of Nebraska Medical Center
- University of New Mexico
- University of Oregon
- University of Texas Health Science Center
- Wayne State University
- West Virginia University Health Sciences Center
- Wake Forest University
- Physiology Department Catalog Submission Form
- Career Gateway
- Diversity, Equity & Inclusion
- About APS
Fatty diet also decreases sensitivity of kidney feedback system
Rockville, Md. (May 19, 2022)—A high-fat diet after 16 weeks induced hypertension in rats, according to researchers from Henry Ford Health and Wayne State University in Detroit. High blood pressure can lead to narrowing of the blood vessels throughout the body, resulting in kidney dysfunction. The study also revealed rats fed a high-fat diet developed insulin resistance after 14 weeks and a decreased sensitivity of the tubuloglomerular feedback (TGF) mechanism, a feedback system in the kidneys that regulates renal function. The findings are published ahead of print in the American Journal of Physiology-Renal Physiology, and the study has been chosen as an APSselect article for the month of May.
The study was conducted in male rats using in vivo renal micropuncture (an examination of areas of the nephron) to measure the TGF response after a high-fat diet at four weeks and 16 weeks. Rats fed a high-fat diet gradually increased in weight but were significantly heavier by week eight of the study. Decreased TGF sensitivity causes less vasoconstriction in a small branch of an artery that feeds blood into the glomerulus (the afferent arteriole). This increases pressure inside the glomerulus, a cluster of capillaries between two resistance arterioles where plasma is filtered from the blood. An increase in glomerular pressure can damage the glomerulus.
Researchers also found that the glomerular pressure was higher in the rats fed a high-fat diet. In addition, glomerulosclerosis (scarring in the tiny blood vessels inside the glomerulus) was higher after 16 weeks of a high-fat diet.
This is the first study to provide direct evidence that obesity caused by a high-fat diet directly affects TGF to change glomerular pressure. The researchers behind this study are among a rare group of physiologists in the world who can perform in vivo measurements to show how this mechanism may cause glomerular injury in obesity. The hope is that more research will lead to therapies targeting TGF or signaling in the kidneys to reduce damage in people with chronic obesity.
Read the full article, “Decreased tubuloglomerular feedback response in high-fat diet-induced obesity.” It is highlighted as one of this month’s “best of the best” as part of the American Physiological Society’s APSselect program. Read all of this month’s selected research articles.
NOTE TO JOURNALISTS: To schedule an interview with a member of the research team, please contact APS Media Relations or call 301.634.7314. Find more research highlights in our Newsroom.
Physiology is a broad area of scientific inquiry that focuses on how molecules, cells, tissues and organs function in health and disease. The American Physiological Society connects a global, multidisciplinary community of more than 10,000 biomedical scientists and educators as part of its mission to advance scientific discovery, understand life and improve health. The Society drives collaboration and spotlights scientific discoveries through its 16 scholarly journals and programming that support researchers and educators in their work.
Related Content
- Short on Sleep? Your Heart May Have a Harder Time Adjusting to Disruptions during Sleep
- Blueberry Extract May Aid Wound Healing
- Researcher Name Changes Now Easier in APS Journals
- Collagen Stiffness Plays Role in Asthma, Could Lead to Targeted Treatment
- Frequent Breaks from Sitting May Improve Daily Blood Sugar Fluctuations
- Nobel Laureate, Esteemed Physiologists to Deliver Prestigious Award Lectures at Experimental Biology
- Researchers Identify Potential Target for Treating Autoimmune Diseases
Contact Us
Communications Department
301.634.7314