- Membership & Community
-
Publications & News
- Physiology Journals
-
Newsroom
-
The Physiologist Magazine
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- In Depth
-
Mentoring Forum
- Net Worth
- Take Care
- You … In Charge
- Work. It. Out.
- Working Off-site
- Location, Location, Location?
- Student Support
- Progressing to Postdoc
- Relationship Building
- Let’s Get It Started
- What Do We Value?
- It’s a Postdoc Life
- Coronavirus Contributions
- Creative Communications
- Selection Process
- Conference Connections
- Postdoc Appreciation
- Research Rewards
- Focus on Teaching
- Industry Insights
- Balance Beam
- Post Postdoc
- If You Build It
- Talk It Through
- Forward Bound
- I’ve Earned My PhD. Now What?
- University Life
- Tips for Trainees
- Time Travel
- Prepare Now for the Career You Want
- Landing a Postdoctoral Researcher Position
- Becoming a Physician-Scientist
- Policy IQ
- Publish with Polish
- Under the Microscope
- Mentoring Q&A
- Evolution
- Baseline by Scott Steen, CAE, FASAE
- Find Us on Social Media
-
The Physiologist Magazine
-
Professional Development
-
Meetings & Events
-
American Physiology Summit
- #APS2024 Overview
- Abstracts
- Awards at the Summit
- Award Lectures
- Career Networking Lunch Form
- Dates and Deadlines
- Hotel Information
- Industry Partners
- Mobile App
- NIH and NSF Program Officer Panel Discussion Form
- Physical Poster Information
- PhysioHub
- Pre-Summit Events
- Registration
- Section & Group Banquet Tickets
- Social Events
- Speaker Audiovisual Instructions
- Summit FAQs
- Summit Newsroom
- Summit Store
- Travel & Transportation
- Undergraduate Program Book
- Liability Waiver
- Industry Partners
- Martin Frank Diversity Travel Award Orientation Agenda
- Martin Frank Diversity Travel Award Networking Luncheon Agenda
- Women in Physiology Networking Event Agenda
-
2023
- APS 2023 Call for Proposals
- Shocklogic Test
- Team 2023 Task Force
- Shaping the Summit
- Schedule at a Glance
- Pre-Summit Events
- Pre-Summit Center for Physiology Education Workshop Registration
- Section & Groups Banquet Tickets
- Summit Store
- Pre-Summit Center for Physiology Education Workshop
- Press Registration
- Meet the Organizers
- Keynote Speaker—Terrie Williams, PhD
- Keynote Speaker—David Julius, PhD
- Industry Workshop Information
- Important Dates and Deadlines
- Hotel Information
- Game Changers
- Distinguished Lecturers
- Building APS 2023
- Awards at the Summit
- 2023 Summit Information
- American Physiology Summit Program
- 2023 Summit Newsroom
- 2024
- Scientific Integrity Policy
- Integrative Physiology of Exercise Conference
- Webinars
- Related Meetings
- Future APS Conferences
-
Past APS Conferences
- APS Institute on Teaching and Learning
- Integrative Physiology of Exercise
- Seventeenth International Conference on Endothelin (ET-17)
- New Trends in Sex and Gender Medicine
- APS Institute on Teaching and Learning (2022)
- Control of Renal Function in Health and Disease Conference
- Comparative Physiology: From Organisms to Omics in an Uncertain World
- Conference Policies
-
American Physiology Summit
- Awards
-
Career & Professional Development
-
Career Gateway
-
Resources
- Transcript—Leading Through Conflict and Difficult Conversations
- Transcript—Managing Conflict with Colleagues
- Transcript—Leading a Team Through Conflict
- Transcript—Providing Difficult Feedback
- Transcript—Team Dynamics and Culture Primer
- Transcript—Building a Team
- Transcript—Leading a Team Assigned to You
- Transcript—Creating a Team Culture
-
Resources
- Career Navigator
- Center for Physiology Education
- Job Board
- Mentoring
- APS Graduate Physiology & Biomedical Science Catalog
-
Career Gateway
-
Meetings & Events
-
Advocacy & Resources
- Policy Areas
-
Resources
- Researcher Resources
- Educator Resources
- Trainee Resources
- Student Resources
-
APS Graduate Physiology & Biomedical Science Catalog
- Des Moines University
- East Tennessee State University
- George Washington University
- Mayo Clinic Graduate School of Biomedical Sciences—Biomedical Engineering & Physiology
- Michigan State University
- New York Medical College
- Nova Southeastern University
- Pennsylvania State University
- Texas A&M University
- Texas A&M University Medical Physiology
- Stony Brook University
- The University of Iowa
- University of Alabama at Birmingham
- University at Buffalo
- University of Colorado
- University of Michigan
- University of Minnesota
- University of Missouri-Biomedical Sciences
- University of Nebraska Medical Center
- University of Oregon
- University of South Carolina School of Medicine
- University of Tennessee Health Science Center (UTHSC)
- University of Texas Health Science Center
- Virginia Commonwealth University
- Wayne State University
- Wake Forest University
- Physiology Department Catalog Submission Form
- Women's Health Research Initiative
- Career Gateway
- Diversity, Equity & Inclusion
- Advocacy
- About APS
Adropin could help prevent obesity- and diabetes-related cardiovascular diseases
Rockville, Md. (September 20, 2022)—New research identifies the importance of the protein adropin in preventing stiffness in the arteries of people with obesity and type 2 diabetes. The study is published ahead of print in the American Journal of Physiology-Heart and Circulatory Physiology.
Arterial stiffness is a condition associated with aging and insulin resistance, a chronic condition associated with obesity, and is a major contributor in the development of cardiovascular disease, including heart attack and stroke.
Adropin, a protein produced by the liver and other tissues, is involved in maintaining energy balance in the body and the metabolism of fat and sugar. Previous studies have suggested that adropin also plays a role in regulating cardiovascular health. People with chronic conditions such as obesity and type 2 diabetes have been found to have lower levels of adropin in the bloodstream.
Researchers reported decreased expression of adropin in the liver was associated with both an elevated body mass index and hemoglobin A1c, a marker of glycemic control, in patients undergoing bariatric surgery. In a separate group, people with type 2 diabetes had lower adropin levels and increased arterial stiffness when compared to healthy controls.
In addition, the researchers studied arteries isolated from mice that were lacking adropin. They reported that “loss of adropin alone causes an increase in arterial stiffness, mimicking the effects of obesity and type 2 diabetes.” The researchers later used adropin to treat arterial stiffening in a mouse model of obesity and type 2 diabetes and found that “adropin exposure reduces obesity and type 2 diabetes-associated arterial stiffening.”
These findings suggest that people with low adropin levels are more likely to develop arterial stiffening and, therefore, greater consideration should be given to adropin as a potential therapeutic target in the prevention and treatment of cardiovascular disease in people with obesity and type 2 diabetes.
Read the full article, “Role of adropin in arterial stiffening associated with obesity and type 2 diabetes,” published ahead of print in the American Journal of Physiology-Heart and Circulatory Physiology.
NOTE TO JOURNALISTS: To schedule an interview with a member of the research team, please contact APS Media Relations or call 301.634.7314. Find more research highlights in our Newsroom.
Physiology is a broad area of scientific inquiry that focuses on how molecules, cells, tissues and organs function in health and disease. The American Physiological Society connects a global, multidisciplinary community of more than 10,000 biomedical scientists and educators as part of its mission to advance scientific discovery, understand life and improve health. The Society drives collaboration and spotlights scientific discoveries through its 16 scholarly journals and programming that support researchers and educators in their work.
Related Content
- Hypertension Disrupts Natural Blood Pressure ‘Dipping’ Rhythm in Both Sexes
- The Heart Grows More in Pregnant Rats with High Blood Pressure
- Skin Wetting Helps Cool Older Adults in Very Hot, Dry Weather
- New American Physiological Society Leaders Take Office
- Combining Two Diabetes Drugs Helps Promote Weight Loss and Blood Sugar Control
- Intermittent Fasting May Help Preserve Intestinal Health as We Age
- American Physiological Society to Launch Subscribe to Open Model for Research Journals
Contact Us
For questions, comments or to share your story ideas, email us.