- Membership & Community
-
Publications & News
- Journals
-
Newsroom
-
The Physiologist Magazine
- 2019
- 2020
- 2021
- 2022
- 2023
-
Mentoring Forum
- Net Worth
- Take Care
- You … In Charge
- Work. It. Out.
- Working Off-site
- Location, Location, Location?
- Student Support
- Progressing to Postdoc
- Relationship Building
- Let’s Get It Started
- What Do We Value?
- It’s a Postdoc Life
- Coronavirus Contributions
- Creative Communications
- Selection Process
- Conference Connections
- Postdoc Appreciation
- Research Rewards
- Focus on Teaching
- Industry Insights
- Balance Beam
- Post Postdoc
- If You Build It
- Talk It Through
- Forward Bound
- I’ve Earned My PhD. Now What?
- University Life
- Mentoring Q&A
- The Physiologist Magazine Readers Survey
- Evolution
- Baseline by Scott Steen, CAE, FASAE
- Find Us on Social Media
-
The Physiologist Magazine
-
Professional Development
-
Meetings & Events
-
American Physiology Summit
- #APS2024 Overview
- Abstracts
- Awards at the Summit
- Dates and Deadlines
- Mobile App
- Physical Poster Information
- PhysioHub
- Registration
- Section & Groups Banquet Tickets
- Speaker Audiovisual Instructions
- Summit FAQs
- Summit Newsroom
- Travel & Transportation
- Liability Waiver
- APS 2024 Call for Proposals
- Industry Partners
-
2023
- APS 2023 Call for Proposals
- Women in Physiology Networking Mixer Registration
- Career Networking Lunch Form
- NIH Program Officer Panel Discussion Form
- Shocklogic Test
- Team 2023 Task Force
- Summit Industry Partners
- Shaping the Summit
- Schedule at a Glance
- Pre-Summit Events
- Pre-Summit Center for Physiology Education Workshop Registration
- Section & Groups Banquet Tickets
- Undergraduate Program Book
- Summit Store
- Pre-Summit Center for Physiology Education Workshop
- Press Registration
- Meet the Organizers
- Keynote Speaker—Terrie Williams, PhD
- Keynote Speaker—David Julius, PhD
- Industry Workshop Information
- Important Dates and Deadlines
- Hotel Information
- Game Changers
- Distinguished Lecturers
- Building APS 2023
- Awards at the Summit
- 2023 Summit Information
- American Physiology Summit Program
- Scientific Integrity Policy
- Webinars
- Related Meetings
- Future APS Conferences
-
Past APS Conferences
- APS Institute on Teaching and Learning
- Integrative Physiology of Exercise
- Seventeenth International Conference on Endothelin (ET-17)
- New Trends in Sex and Gender Medicine
- APS Institute on Teaching and Learning (2022)
- Control of Renal Function in Health and Disease Conference
- Comparative Physiology: From Organisms to Omics in an Uncertain World
- Conference Policies
-
American Physiology Summit
- Awards
-
Career & Professional Development
-
Career Gateway
-
Resources
- Transcript—Leading Through Conflict and Difficult Conversations
- Transcript—Managing Conflict with Colleagues
- Transcript—Leading a Team Through Conflict
- Transcript—Providing Difficult Feedback
- Transcript—Team Dynamics and Culture Primer
- Transcript—Building a Team
- Transcript—Leading a Team Assigned to You
- Transcript—Creating a Team Culture
-
Resources
- Career Navigator
- Center for Physiology Education
- Job Board
- Professional Skills Training Courses
- Medical Physiology Refreshers
- Mentoring
- APS Graduate Physiology & Biomedical Science Catalog
-
Career Gateway
-
Meetings & Events
-
Advocacy & Resources
- Policy Areas
-
Resources
- Researcher Resources
- Educator Resources
- Trainee Resources
- Student Resources
-
APS Graduate Physiology & Biomedical Science Catalog
- Augusta University
- Brandeis University
- Des Moines University
- East Tennessee State University
- George Washington University
- Louisiana State University Health Sciences Center Shreveport
- Mayo Clinic Graduate School of Biomedical Sciences—Biomedical Engineering & Physiology
- Medical College of Wisconsin
- Michigan State University
- New York Medical College
- Nova Southeastern University
- Pennsylvania State University
- Saint Louis University
- Texas A&M University
- Texas A&M University Medical Physiology
- Stony Brook University
- The University of Iowa
- The University of Mississippi Medical Center
- The University of Tennessee Health Science Center (UTHSC)
- University of Alabama at Birmingham
- University at Buffalo
- University of Colorado
- University of Delaware
- University of Florida
- University of Louisville
- University of Michigan
- University of Minnesota
- University of Missouri-Biomedical Sciences
- University of Nebraska Medical Center
- University of New Mexico
- University of South Carolina School of Medicine
- University of Texas Health Science Center
- Virginia Commonwealth University
- Wayne State University
- Wake Forest University
- Physiology Department Catalog Submission Form
- Career Gateway
- Diversity, Equity & Inclusion
- Advocacy
- About APS
Rockville, Md. (October 12, 2023)—Improving insulin resistance with metformin, a medication used to treat Type 2 diabetes, reduced the chances of developing kidney disease in a prepubescent obese rat model, according to a new study from the University of Mississippi Medical Center. Treatment with metformin also reduced early signs of inflammation and dyslipidemia (imbalance of fats such as cholesterol and triglycerides). Obesity and insulin resistance are risk factors for developing metabolic disease such as Type 2 diabetes and play a major role in the early stages of kidney disease, including protein in the urine (proteinuria). The study is published in the American Journal of Physiology-Renal Physiology and has been chosen as an APSselect article for October.
“The major goal of this research was to determine if insulin resistance plays a role in the early progression of renal disease associated with prepubertal obesity.” —Jan Michael Williams, PhD
Studies investigating the role of childhood insulin resistance and obesity-related kidney injury are limited. This research provides evidence of an early relationship between the two conditions. Researchers gave 60 young male and female rats a constant supply of food and water during the study. A second group of obese, salt-sensitive rats ate either normal food or food containing metformin.
At the end of the study, there was a significant decrease in body weight and plasma insulin levels in metformin-treated rats compared to control rats that did not receive the medication. In addition, the metformin-treated animals had lower levels of proteinuria.
“Prepubertal obesity is currently an epidemic and is considered a major risk factor for renal injury,” said Jan Michael Williams, PhD, lead author of the study. “The results from our study suggest treatments that reduce insulin resistance may slow the early progression of renal disease in obese children, which may ultimately prevent the development of chronic kidney disease in adulthood.”
Read the full article, “Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats.” It is highlighted as one of this month’s “best of the best” as part of the American Physiological Society’s APSselect program. Read all of this month’s selected research articles.
NOTE TO JOURNALISTS: To schedule an interview with a member of the research team, please contact APS Media Relations or call 301.634.7314. Find more research highlights in our Newsroom.
Physiology is a broad area of scientific inquiry that focuses on how molecules, cells, tissues and organs function in health and disease. The American Physiological Society connects a global, multidisciplinary community of more than 10,000 biomedical scientists and educators as part of its mission to advance scientific discovery, understand life and improve health. The Society drives collaboration and spotlights scientific discoveries through its 16 scholarly journals and programming that support researchers and educators in their work.
Related Content
- Coconut Sugar May Lower Blood Pressure, Artery Stiffness in Older Adults
- The Physiologist Magazine
- Climate Change Negatively Affecting School Sharks
- Fat Isn’t Necessarily Bad! Full-fat Yogurt Helps Lower Glucose Levels in People with Prediabetes
- Opioid Exposure in the Womb Could Raise the Risk of Heart Disease Later in Life
- Announcing Virtual Press Conference for the American Physiology Summit
- ‘Scratch and Sniff’ Test Sheds Light on Depression
Contact Us
Communications Department
844.526.1700