WEBINAR—New Frontiers in Protein Trafficking

August 11, 2020
4-5:30 p.m. EDT

Now available on demand

Join the American Journal of Physiology-Cell Physiology, published by the American Physiological Society, for a symposium to showcase the recent acceleration and expansion of research into endosomal networking and protein trafficking to specific membrane domains. The emerging roles of the retromer and retriever complexes and sorting nexins in epithelial cells will also be discussed.

Leading researchers in molecular physiology and the biology of retromer, retriever and sorting nexins will present their most recent findings about these multi-protein complex systems, which are the core of the protein-sorting processes of animal cells.

Moderators

Josephine Adams, PhD, University of Bristol, U.K., editor-in-chief, American Journal of Physiology-Cell Physiology
Kirk Hamilton, PhD, University of Otago, New Zealand, associate editor, American Journal of Physiology-Cell Physiology

Speakers

Structural biology studies of endosomal trafficking by retromer and retriever complexes
Brett Collins, PhD, University of Queensland, Australia

Collin's work provides important insight into the architecture of the retromer coat and its mechanism of assembly, and suggests that retromer promotes tubule formation by directing the distribution of sorting nexin proteins on the membrane surface while providing a scaffold for regulatory-protein interactions.

Novel findings on the role of retromer and the retriever complex in the recycling of the epithelial sodium channel ENaC
Fiona McDonald, PhD, University of Otago, New Zealand

McDonald's work is the first to indicate that these protein complexes are crucial for delivery of ENaC to the cell surface.